In this taut and fascinating novel, the bestselling, New York Times bestselling and National Book Award-winning author of The Sacrifice, The Accursed, and Lovely, Dark, Deep examines the mysteries of memory, personality, and identity and pierces the enigmatic force that drives human lives—love.

In 1965, neuroscientist Margot Sharpe meets the attractive, charismatic Elihu Hoopes—the “man without a shadow”—whose devastated memory, unable to store new experiences or to retrieve the old, will make him the most famous and most studied amnesiac in history. Over the course of the next thirty years, Margot herself becomes famous for her experiments with E. H.—and inadvertently falls in love with him, despite the ethical ambiguity of their affair, and though he remains forever elusive and mysterious to her, haunted by mysteries of the past.

The Man Without a Shadow tracks the intimate, illicit relationship between Margot and Eli, as scientist and subject embark upon an exploration of the labyrinthine mysteries of the human brain. Where does “memory” reside? Where is “love”? Is it possible to love an individual who cannot love you, who cannot “remember” you from one meeting to the next?